PVRL1 antibody (N-Term)

Catalog No. ABIN2788762

Product Details anti-PVRL1 Antibody

Target: PVRL1 (Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PVRL1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QLNLTVMAKP TNWIEGTQAV LRAKKGQDDK VLVATCTSAN GKPPSVVSWE

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PVRL1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 517 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PVRL1

Target: PVRL1 (Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1))

Alternative Name: PVRL1 (PVRL1 Products)

Synonyms: CD111 antibody, CLPED1 antibody, ED4 antibody, HIgR antibody, HVEC antibody, OFC7 antibody, PRR antibody, PRR1 antibody, PVRR antibody, PVRR1 antibody, SK-12 antibody, nectin-1 antibody, prr1 antibody, PVRL1 antibody, pvrl1 antibody, AI835281 antibody, AW549174 antibody, Cd111 antibody, HveC antibody, cd111 antibody, cd112 antibody, clped1 antibody, ed4 antibody, higr antibody, hveb antibody, hvec antibody, nectin-2 antibody, ofc7 antibody, prr antibody, prr2 antibody, pvrl2 antibody, pvrl2.L antibody, pvrr antibody, pvrr1 antibody, pvrr2 antibody, sk-12 antibody, nectin cell adhesion molecule 1 antibody, nectin-1 antibody, Poliovirus receptor-related protein 1 antibody, poliovirus receptor-related 1 (herpesvirus entry mediator C) antibody, nectin cell adhesion molecule 2 L homeolog antibody, NECTIN1 antibody, LOC100145553 antibody, pvrl1 antibody, nectin1 antibody, Nectin1 antibody, PVRL1 antibody, nectin2.L antibody

Background: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Alias Symbols: CD111, CLPED1, ED4, HIgR, HVEC, MGC142031, MGC16207, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1
Protein Interaction Partner: UBC, PVRL4, PVRL3, PVRL1, PARD3, PRNP, PVR, MLLT4,
Protein Size: 517

Molecular Weight: 57 kDa

Gene ID: 5818

NCBI Accession: NM_002855, NP_002846

UniProt: Q15223

Pathways: Cell-Cell Junction Organization