PKN2 antibody (C-Term)

Catalog No. ABIN2788942

Product Details anti-PKN2 Antibody

Target: PKN2 (Protein Kinase N2 (PKN2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Zebrafish (Danio rerio), Dog, Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKN2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LRRNPERRLG AGEKDAEDVK KHPFFRLTDW SALMDKKVKP PFVPTIRGRE

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 77%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against Pkn2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Pkn2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PKN2

Target: PKN2 (Protein Kinase N2 (PKN2))

Alternative Name: Pkn2 (PKN2 Products)

Synonyms: PAK2 antibody, PRK2 antibody, PRKCL2 antibody, PRO2042 antibody, Pak-2 antibody, 6030436C20Rik antibody, AI507382 antibody, Prkcl2 antibody, Stk7 antibody, pak2 antibody, prk2 antibody, pak-2 antibody, pro2042 antibody, PKN2 antibody, si:ch211-83f14.1 antibody, wu:fa97c07 antibody, protein kinase N2 antibody, protein kinase N2 L homeolog antibody, PKN2 antibody, Pkn2 antibody, pkn2.L antibody, pkn2 antibody

Background: Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF).
Alias Symbols: 6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7
Protein Size: 983

Molecular Weight: 111 kDa

Gene ID: 109333

NCBI Accession: NM_178654, NP_848769

UniProt: Q8BWW9

Pathways: Cell-Cell Junction Organization