Trip7 antibody, PNAS-25 antibody, TRIP7 antibody, 1110002A15Rik antibody, 6330514M13Rik antibody, BB071015 antibody, high mobility group nucleosomal binding domain 3 L homeolog antibody, high mobility group nucleosomal binding domain 3 antibody, hmgn3.L antibody, HMGN3 antibody, Hmgn3 antibody
Background
Hmgn3 binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. It affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion, regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors and regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. It may play a role in ocular development and astrocyte function. Alias Symbols: 1110002A15Rik, 6330514M13Rik, BB071015, TRIP7 Protein Size: 99