TNIP3 antibody (N-Term)

Catalog No. ABIN2790314

Product Details anti-TNIP3 Antibody

Target: TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNIP3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YERKVAELKT KLDAAERFLS TREKDPHQRQ RKDDRQREDD RQRDLTRDRL

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against TNIP3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TNIP3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 256 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNIP3

Target: TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))

Alternative Name: TNIP3 (TNIP3 Products)

Synonyms: ABIN-3 antibody, LIND antibody, 9030611K07Rik antibody, TNIP3 antibody, TNFAIP3 interacting protein 3 antibody, TNIP3 antibody, Tnip3 antibody

Background: TNIP3 binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Alias Symbols: ABIN-3, FLJ21162, LIND
Protein Interaction Partner: ZBTB8A, NOTCH2NL, KRTAP10-3, KRTAP10-8, KRT40, LZTS2, TNIP1, DAZAP2, TAX1BP1, UBC, TNFAIP3, NFKB1,
Protein Size: 256

Molecular Weight: 27 kDa

Gene ID: 79931

NCBI Accession: NM_001128843

UniProt: Q96KP6

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin