PREX2 antibody (N-Term)

Catalog No. ABIN2791874

Product Details anti-PREX2 Antibody

Target: PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PREX2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ERDYVGTLEF LVSAFLHRMN QCAASKVDKN VTEETVKMLF SNIEDILAVH

Predicted Reactivity: Cow: 93%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against PREX2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PREX2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PREX2

Target: PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))

Alternative Name: PREX2 (DEPDC2 Products)

Synonyms: 6230420N16Rik antibody, DEP.2 antibody, DEPDC2 antibody, P-REX2 antibody, AI316880 antibody, AI553603 antibody, C030045D06Rik antibody, D430013K02 antibody, Depdc2 antibody, P-Rex2 antibody, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 antibody, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 antibody, PREX2 antibody, Prex2 antibody

Background: PREX2 functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. PREX2 mediates the activation of RAC1 in a PI3K-dependent manner. PREX2 may be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
Protein Interaction Partner: PPP1CA, MTOR, TGFBR1,
Protein Size: 1606

Molecular Weight: 182 kDa

Gene ID: 80243

UniProt: Q70Z35