NAPA antibody (N-Term)
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- Target See all NAPA Antibodies
- NAPA (N-Ethylmaleimide-Sensitive Factor Attachment Protein, alpha (NAPA))
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Binding Specificity
- N-Term
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Reactivity
- Mouse, Cow, Dog, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NAPA antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MDNSGKEAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Mouse: 78%, Zebrafish: 78%
- Characteristics
- This is a rabbit polyclonal antibody against NAPA. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human NAPA
- Top Product
- Discover our top product NAPA Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 295 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NAPA (N-Ethylmaleimide-Sensitive Factor Attachment Protein, alpha (NAPA))
- Alternative Name
- NAPA (NAPA Products)
- Synonyms
- SNAPA antibody, wu:fa26c04 antibody, zgc:63906 antibody, napb antibody, 1500039N14Rik antibody, AW209189 antibody, RA81 antibody, SNARE antibody, a-SNAP antibody, hyh antibody, alpha-SNAP antibody, Alpha-SNAP antibody, NSF attachment protein alpha antibody, N-ethylmaleimide-sensitive factor attachment protein, alpha b antibody, NSF attachment protein alpha L homeolog antibody, N-ethylmaleimide-sensitive factor attachment protein, alpha antibody, N-ethylmaleimide sensitive fusion protein attachment protein alpha antibody, soluble NSF attachment protein antibody, NAPA antibody, napab antibody, napa.L antibody, napa antibody, EHI_000300 antibody, Napa antibody, LOC102577508 antibody
- Background
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The 'SNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes. According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle targeting and docking through mutual recognition. Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex. Alpha- and gamma-SNAP are found in a wide range of tissues and act synergistically in intra-Golgi transport. The sequence of the predicted 295-amino acid human protein encoded by NAPA shares 37 % , 60 %, and 67 % identity with the sequences of yeast, Drosophila, and squid alpha-SNAP, respectively.
Alias Symbols: SNAPA
Protein Interaction Partner: UBC, RPA3, RPA2, RPA1, RNF2, ATP4A, STX5, ITGA4, FN1, VCAM1, VCP, DHX40, DHX29, THUMPD3, STAM2, VAMP2, APP, NSF, TRPC3, RTN4, STX12, GNA12, STX8, GOSR2, GOSR1, BNIP1, STX7, VAMP8, SNAP23, STX4, STX1A, SNAP25,
Protein Size: 295 - Molecular Weight
- 33 kDa
- Gene ID
- 8775
- NCBI Accession
- NM_003827, NP_003818
- UniProt
- P54920
- Pathways
- Synaptic Vesicle Exocytosis, Asymmetric Protein Localization
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