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PON2 antibody

PON2 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2855759
  • Target See all PON2 Antibodies
    PON2 (Paraoxonase 2 (PON2))
    Reactivity
    • 62
    • 25
    • 17
    Human
    Host
    • 57
    • 3
    • 2
    • 1
    Rabbit
    Clonality
    • 53
    • 10
    Polyclonal
    Conjugate
    • 25
    • 7
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This PON2 antibody is un-conjugated
    Application
    • 43
    • 34
    • 33
    • 14
    • 14
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Rabbit Polyclonal antibody to PON2 (paraoxonase 2)
    PON2 antibody [N1C2]
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human PON2. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product PON2 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: A431 , Mouse liver

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Devarajan, Su, Grijalva, Yalamanchi, Yalamanchi, Gao, Trost, Nwokedi, Farias-Eisner, Farias-Eisner, Fogelman, Reddy: "Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer." in: Cell death & disease, Vol. 9, Issue 3, pp. 392, (2019) (PubMed).

  • Target
    PON2 (Paraoxonase 2 (PON2))
    Alternative Name
    paraoxonase 2 (PON2 Products)
    Synonyms
    PON2 antibody, pon1 antibody, MGC53915 antibody, pon2 antibody, 6330405I24Rik antibody, AI481612 antibody, serum paraoxonase/arylesterase 2 antibody, paraoxonase 2 antibody, paraoxonase 2 L homeolog antibody, Serum paraoxonase/arylesterase 2 antibody, LOC100303695 antibody, PON2 antibody, pon2.L antibody, BDBG_00600 antibody, pon2 antibody, Pon2 antibody
    Background
    This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

    Cellular Localization: Membrane, Peripheral membrane protein
    Molecular Weight
    39 kDa
    Gene ID
    5445
    UniProt
    Q15165
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