Desmocollin 2 antibody

Catalog No. ABIN2856641

Product Details anti-Desmocollin 2 Antibody

Target: Desmocollin 2 (DSC2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to Desmocollin 2 (desmocollin 2)
Desmocollin 2 antibody [C1C2], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Desmocollin 2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for Desmocollin 2

Target: Desmocollin 2 (DSC2)

Alternative Name: desmocollin 2 (DSC2 Products)

Synonyms: ARVD11 antibody, CDHF2 antibody, DG2 antibody, DGII/III antibody, DSC3 antibody, AW228162 antibody, Dsc2a antibody, Dsc2b antibody, DSC2 antibody, desmocollin 2 antibody, DSC2 antibody, Dsc2 antibody

Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Cellular Localization: Cell membrane , Cell junction , desmosome

Molecular Weight: 100 kDa

Gene ID: 1824

UniProt: Q02487