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Details for Product No. ABIN302199

CD105 (Endoglin / TGF-Beta1/3 Receptor) antibody (FITC)

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Antigen
Synonyms CD105, AI528660, AI662476, S-endoglin, END, HHT1, ORW1
Reactivity
»Alternatives Human, Pig (Porcine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
Application
»Alternatives Flow Cytometry (FACS)
Pubmed 5 references available
Catalog no. ABIN302199
Quantity 100 tests
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA
Clone MEM-229
Isotype IgG2a
Characteristics Synonyms: ENG, END, HHT1, ORW, ORW1
Alternative Name CD105 / Endoglin
Background CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence ofTGFbR-2 as a receptor for TGFb-1 and TGFb-3. CD105 is highly expressed on endothelialcells and promotes angiogenesis during wound healing, infarcts and in a wide range oftumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis inhypoxic endothelial cells and also antagonises the inhibitory effects of TGFb-1 on vascularendothelial cell growth and migration. Normal cellular levels of CD105 are required forformation of new blood vessels.
UniProt P17813
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry analysis of human blood cells using 20 l reagent / 100 l of whole bloodor 10e6 cells in a suspension. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS 15 mM Sodium Azide 0.2% (w/v) high-grade protease free BSA
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Li, Issa, Kumar et al.: "CD105 prevents apoptosis in hypoxic endothelial cells." in: Journal of cell science, Vol. 116, Issue Pt 13, pp. 2677-85, 2003 (PubMed).

Zhu, Sun, Xie et al.: "Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells." in: Stroke; a journal of cerebral circulation, Vol. 34, Issue 10, pp. 2483-8, 2003 (PubMed).

Guo, Slevin, Li et al.: "CD105 inhibits transforming growth factor-beta-Smad3 signalling." in: Anticancer research, Vol. 24, Issue 3a, pp. 1337-45, 2004 (PubMed).

Warrington, Hillarby, Li et al.: "Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells." in: Anticancer research, Vol. 25, Issue 3B, pp. 1851-64, 2005 (PubMed).

Piao, Tokunaga: "Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study." in: Journal of atherosclerosis and thrombosis, Vol. 13, Issue 2, pp. 82-9, 2006 (PubMed).

Alternatives for antigen "CD105 (Endoglin / TGF-Beta1/3 Receptor)", type "Antibodies"
Hosts (147), (121), (46), (3), (2)
Reactivities (231), (101), (37), (28), (23), (13), (13), (6), (1)
Applications (197), (179), (72), (64), (56), (45), (29), (27), (18), (16), (15), (9), (8), (7), (4), (4), (1)
Conjugates (29), (26), (23), (8), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (9), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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