SDHA antibody (N-Term)

Catalog No. ABIN3043074

Product Details anti-SDHA Antibody

Target: SDHA (Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA))

Binding Specificity: AA 113-128, N-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SDHA antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Succinate dehydrogenase[ubiquinone] flavoprotein subunit, mitochondrial(SDHA) detection. Tested with WB in Human,Mouse,Rat.

Sequence: NMEEDNWRWH FYDTVK

Cross-Reactivity (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Succinate dehydrogenase[ubiquinone] flavoprotein subunit, mitochondrial(SDHA) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: succinate dehydrogenase complex, subunit A, flavoprotein(Fp)
Protein Name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human SDHA(113-128aa NMEEDNWRWHFYDTVK), identical to the related rat and mouse sequences.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SDHA

Target: SDHA (Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA))

Alternative Name: SDHA (SDHA Products)

Synonyms: CG17246 antibody, Dmel\\CG17246 antibody, Scs-fp antibody, Sdh antibody, Sdha antibody, scs-fp antibody, sdh antibody, CMD1GG antibody, FP antibody, PGL5 antibody, SDH1 antibody, SDH2 antibody, SDHF antibody, 1500032O14Rik antibody, 2310034D06Rik antibody, 4921513A11 antibody, C81073 antibody, im:7141001 antibody, zgc:56051 antibody, Fp antibody, sdha-b antibody, Succinate dehydrogenase, subunit A (flavoprotein) antibody, succinate dehydrogenase complex flavoprotein subunit A antibody, succinate dehydrogenase complex, subunit A, flavoprotein (Fp) antibody, succinate dehydrogenase complex subunit A, flavoprotein (Fp) S homeolog antibody, SdhA antibody, SDHA antibody, Sdha antibody, sdha antibody, sdha.S antibody

Background: SDHA(Succinate dehydrogenase complex, subunit a, flavoprotein), also called SDH1, HOMOLOG OF, is a protein that in humans is encoded by the SDHA gene. The SDHA gene is mapped on 5p15.33. The SDHA gene is highly polymorphic. The gene that codes for the SDHA protein is nuclear, even though the protein is located in the inner membrane of the mitochondria. Heterozygous carriers of an SDHA mutation do not developparagangliomas as has been seen for mutations in the other subunits. In vitro functional expression studies in the yeast homolog showed that the mutation resulted in a loss of SDH activity and rendered the mutant SDHA protein more susceptible to proteolysis. The findings indicated that SDHA, like other SDH subunits, can act as a tumor suppressor gene.

Synonyms: CMD1GG antibody|DHSA_HUMAN antibody|Flavoprotein subunit of complex II antibody|Fp antibody|PGL5 antibody|SDH 2 antibody|SDH1 antibody|SDH2 antibody|SDHA antibody|SDHF antibody|Succinate dehydrogenase[ubiquinone] flavoprotein subunit antibody|Succinate dehydrogenase[ubiquinone] flavoprotein subunit mitochondrial antibody|Succinate dehydrogenase[ubiquinone] flavoprotein subunit, mitochondrial antibody|Succinate dehydrogenase complex flavoprotein subunit antibody|Succinate dehydrogenase complex flavoprotein subunit precursor antibody|Succinate dehydrogenase complex subunit A antibody|Succinate Dehydrogenase Complex subunit A Flavoprotein antibody

UniProt: P31040