PPAP2A antibody

Catalog No. ABIN306892

This Rabbit Polyclonal antibody specifically detects PPAP2A in WB. It exhibits reactivity toward Human.

Quick Overview for PPAP2A antibody (ABIN306892)

Target: PPAP2A (Phosphatidic Acid Phosphatase Type 2A (PPAP2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPAP2A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PPAP2A Antibody

Purpose: Rabbit anti Human Lysophospholipid Phosphatase (LPP) 1/1A

Cross-Reactivity: Human

Characteristics: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. It catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG), and is a pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. It is a major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. It may control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. Its down-regulation may contribute to the development of colon adenocarcinoma.

Immunogen: Synthetic peptide derived from the LPP1 protein

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for PPAP2A

Target: PPAP2A (Phosphatidic Acid Phosphatase Type 2A (PPAP2A))

Alternative Name: Lysophospholipid Phosphatase (LPP) 1/1A

Background: EC 3.1.3.4, Lipid Phosphate Phosphatase 1, Phosphatidic acid phosphatase 2a

UniProt: O14494

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway