LKB1 antibody

Catalog No. ABIN306955

This Rabbit Polyclonal antibody specifically detects LKB1 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for LKB1 antibody (ABIN306955)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LKB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LKB1 Antibody

Purpose: Rabbit anti Human LKB1/STK11 Serine/Threonine Kinase

Cross-Reactivity: Human

Characteristics: Germline mutations of the LKB1 (STK11) tumor suppressor gene can lead to Peutz-Jeghers syndrome (PJS) and a marked predisposition to cancer. LKB1 encodes a serine/threonine kinase that is inactivated in PJS. The tumor suppressor protein PTEN is a LKB1-interacting protein. Several point mutations in LKB1 are associated with PJS and may disrupt the interaction with PTEN suggesting that the loss of this interaction might contribute to PJS. PTEN and LKB1 are predominantly cytoplasmic and nuclear, respectively, the interaction of the two leads to a cytoplasmic relocalization of LKB1. PTEN is a substrate of the kinase LKB1 in vitro.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the human LKB1/STK11 serine/threonine kinase protein.

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Alternative Name: LKB1/STK11 Serine/Threonine Kinase

Background: Serine/threonine-protein kinase 11, Serine/threonine-protein kinase LKB1

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect