Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) (N-Term) antibody

Details for Product No. ABIN310100
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Antigen
Synonyms MGC53243, HNRPC, AL022939, D14Wsu171e, Hnrpc, Hnrpc1, Hnrpc2, hnRNPC1, hnRNPC2, hnrnp-C, bZ1G18.4, fb57h12, fi16b11, wu:fb57h12, wu:fi16b11, zgc:55701, C1, C2, HNRNP, SNRPC, hnRNP C, HNRNPC
Epitope
N-Term
(12), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Dog (Canine), Human
(50), (33), (32), (13), (12), (4), (4), (4), (2), (2), (1)
Host
Rabbit
(44), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(42), (22), (22), (18), (13), (12), (12), (10), (7)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN310100
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human HNRPC
Sequence LDINLAAEPK VNRGKAGVKR SAAEMYGSVT EHPSPSPLLS SSFDLDYDFQ
Predicted Reactivity Human : 100 %, Mouse : 90 %, Rabbit : 90 %, Rat : 90 %
Characteristics This is a rabbit polyclonal antibody against HNRPC. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HNRPC
Background HNRPC belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein can act as a tetramer and is involved in the assembly of 40S hnRNP particles.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has one RRM domain that binds to RNAs. Two alternatively spliced transcript variants have been described for this gene.
Molecular Weight 33 kDa
Gene ID 3183
NCBI Accession NP_112604, NM_031314
UniProt P07910
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 303 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) (N-Term) antibody WB Suggested Anti-HNRPC Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
Background publications Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Validation Images
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