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Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) (N-Term) antibody

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Antigen
Synonyms MGC53243, HNRPC, AL022939, D14Wsu171e, Hnrpc, Hnrpc1, Hnrpc2, hnRNPC1, hnRNPC2, hnrnp-C, bZ1G18.4, fb57h12, fi16b11, wu:fb57h12, wu:fi16b11, zgc:55701, C1, C2, HNRNP, SNRPC, hnRNP C, HNRNPC
Epitope
N-Term
(27), (8), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
(76), (40), (35), (8), (5), (4), (3), (3), (3), (2), (1)
Host
Rabbit
(70), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(62), (31), (30), (23), (18), (11), (9), (8), (2), (1), (1), (1)
Pubmed 2 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human HNRPC
Blocking Peptide Blocking peptide for this product available: ABIN978104
Sequence LDINLAAEPK VNRGKAGVKR SAAEMYGSVT EHPSPSPLLS SSFDLDYDFQ
Predicted Reactivity Human : 100 %, Mouse : 90 %, Rabbit : 90 %, Rat : 90 %
Characteristics This is a rabbit polyclonal antibody against HNRPC. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HNRPC (HNRNPC Antibody Abstract)
Background HNRPC belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein can act as a tetramer and is involved in the assembly of 40S hnRNP particles.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has one RRM domain that binds to RNAs. Two alternatively spliced transcript variants have been described for this gene.
Molecular Weight 33 kDa
Gene ID 3183
NCBI Accession NP_112604, NM_031314
UniProt P07910
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 303 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) (N-Term) antibody (ABIN310100) WB Suggested Anti-HNRPC Antibody Titration: 0.2-1 ug/ml
Positive Control...
Product cited in: Hayakawa, Fujikane, Ito et al.: "Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress." in: Biochemical and biophysical research communications, Vol. 403, Issue 2, pp. 220-4, 2010 (PubMed).

Background publications Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network. ..." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Catalog No. ABIN310100
$289.00
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