CYP2C9 antibody (C-Term)

Catalog No. ABIN310228

This Rabbit Polyclonal antibody specifically detects CYP2C9 in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Cow, Dog, Guinea Pig, Pig, Rabbit and Sheep.

Quick Overview for CYP2C9 antibody (C-Term) (ABIN310228)

Target: CYP2C9 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9))

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog, Guinea Pig, Pig, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP2C9 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CYP2C9 Antibody

Binding Specificity: C-Term

Sequence: AGMELFLFLT SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV

Predicted Reactivity: Cow: 85%, Dog: 83%, Guinea Pig: 75%, Horse: 83%, Human: 100%, Mouse: 83%, Pig: 83%, Rabbit: 77%, Rat: 83%, Sheep: 83%

Characteristics: This is a rabbit polyclonal antibody against CYP2C9. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CYP2C9

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 490 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CYP2C9

Target: CYP2C9 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9))

Alternative Name: CYP2C9

Background: CYP2C9 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that CYP2C9 gene is polymorphic.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CPC9, CYP2C, CYP2C10, MGC149605, MGC88320, P450 MP-4, P450 PB-1, P450IIC9, CYPIIC9
Protein Interaction Partner: POR, CYP2D6, STAMBP, STAT5A, RNF32, ECSIT, MAST1, CDC37, RAB3D,
Protein Size: 490

Molecular Weight: 55 kDa

Gene ID: 1559

NCBI Accession: NM_000771, NP_000762

UniProt: P11712