CYP2C9 antibody (N-Term)

Catalog No. ABIN1882233

Product Details anti-CYP2C9 Antibody

Target: CYP2C9 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9))

Binding Specificity: AA 82-110, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CYP2C9 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This CYP2C9 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the N-terminal region of human CYP2C9.

Clone: 682CT5-6-2

Isotype: IgM

Application Details

Application Notes: WB: 1:100~1600

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CYP2C9 antibody (ABIN1882233)

Yang, Cui, Hasi, Jia, Gong, Su: "Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China." in: Genetics and molecular research : GMR, Vol. 9, Issue 3, pp. 1844-51, (2010) (PubMed).

Ikejiri, Wada, Sakamoto, Ito, Nishioka, Nakatani, Tsuji, Yamada, Nakamura, Ito, Nobori: "The association of protein S Tokushima-K196E with a risk of deep vein thrombosis." in: International journal of hematology, Vol. 92, Issue 2, pp. 302-5, (2010) (PubMed).

Schelleman, Brensinger, Chen, Finkelman, Rieder, Kimmel: "New genetic variant that might improve warfarin dose prediction in African Americans." in: British journal of clinical pharmacology, Vol. 70, Issue 3, pp. 393-9, (2010) (PubMed).

Target Details for CYP2C9

Target: CYP2C9 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9))

Alternative Name: CYP2C9 (CYP2C9 Products)

Synonyms: CPC9 antibody, CYP2C antibody, CYP2C10 antibody, CYPIIC9 antibody, P450IIC9 antibody, cytochrome P450 family 2 subfamily C member 9 antibody, CYP2C9 antibody

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Molecular Weight: 55628

NCBI Accession: NP_000762

UniProt: P11712