Protein Kinase C, zeta (PRKCZ) (N-Term) antibody

Details for Product No. ABIN310404
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Antigen
Synonyms TPKC, PKCzeta, prkcz-A, pkc-zeta, PRKCZ, pkc2, PKC-ZETA, PKC2, AI098070, C80388, Pkcz, R74924, aPKCzeta, zetaPKC, 14-3-3-zetaisoform, r14-3-3, pkcz, si:ch211-150o23.4
Epitope
N-Term
(34), (21), (12), (11), (7), (6), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
(140), (96), (93), (24), (12), (12), (12), (2), (1), (1), (1)
Host
Rabbit
(154), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Western Blotting (WB)
(104), (66), (66), (34), (31), (30), (13), (6), (6), (2), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN310404
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human PRKCZ
Sequence MDSVMPSQEP PVDDKNEDAD LPSEETDGIA YISSSRKHDS IKDDSEDLKP
Predicted Reactivity Human : 100 %, Mouse : 90 %, Rat : 90 %, Bovine : 70 %, Dog : 70 %, Guinea pig : 70 %, Horse : 70 %
Characteristics This is a rabbit polyclonal antibody against PRKCZ. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PRKCZ
Background Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC.Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
Molecular Weight 45 kDa
Gene ID 5590
NCBI Accession NM_001033581, NP_001028753
UniProt Q05513
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 409 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Protein Kinase C, zeta (PRKCZ) (N-Term) antibody WB Suggested Anti-PRKCZ Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
Background publications Xie, Dong, Zhang et al.: "Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells." in: The Journal of biological chemistry, Vol. 281, Issue 10, pp. 6366-75, 2006 (PubMed).

Validation Images
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