F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) (Middle Region) antibody

Details for Product No. ABIN310431
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Antigen
Synonyms fbxl5, MGC53238, FBXL5, FBL4, FBL5, FLR1, Fbl4, Fir4, wu:fb52d06
Epitope
Middle Region
(9), (8), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human
(36), (17), (12), (12), (12), (12), (12)
Host
Rabbit
(34), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(27), (14), (12), (10), (10), (6), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN310431
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Immunogen Synthetic peptide directed towards the middle region of human FBXL5
Sequence VHWARGDWYS GPATELDTEP DDEWVKNRKD ESRAFHEWDE DADIDESEES
Predicted Reactivity Human : 100 %, Dog : 90 %, Horse : 90 %, Mouse : 90 %, Pig : 90 %, Rat : 90 %, Bovine : 80 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against FBXL5. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name FBXL5
Background FBXL5 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXL5 belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.
Molecular Weight 76 kDa
Gene ID 26234
NCBI Accession NM_012161, NP_036293
UniProt Q9UKA1
Research Area Proteolysis / Ubiquitin
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 691 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) (Middle Region) antibody WB Suggested Anti-FBXL5 Antibody Titration: 5.0ug/ml
Positive Control: HepG2 cell lysate
Background publications Ilyin, Rialland, Pigeon et al.: "cDNA cloning and expression analysis of new members of the mammalian F-box protein family." in: Genomics, Vol. 67, Issue 1, pp. 40-7, 2000 (PubMed).

Validation Images
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