C1QB antibody (C-Term)

Catalog No. ABIN310587

Cited in 6+ publications. The Rabbit Polyclonal anti-C1QB antibody (ABIN310587) specifically detects C1QB in IHC and WB. The antibody is reactive with Human, Dog and Horse samples.

Quick Overview for C1QB antibody (C-Term) (ABIN310587)

Target: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Reactivity: Human, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1QB antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-C1QB Antibody

Binding Specificity: C-Term

Purpose: C1QB Antibody - C-terminal region

Sequence: AYNTFQVTTG GMVLKLEQGE NVFLQATDKN SLLGMEGANS IFSGFLLFPD

Predicted Reactivity: Dog: 92%, Horse: 82%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against C1QB. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human C1QB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8097862

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-C1QB antibody (ABIN310587)

Takamori, Atsuta, Nakamura, Sawase, Koyano, Hara: "Histopathological comparison of the onset of peri-implantitis and periodontitis in rats." in: Clinical oral implants research, Vol. 28, Issue 2, pp. 163-170, (2016) (PubMed).

Noguchi, Ukai, Kuramoto, Yoshinaga, Nakamura, Takamori, Yamashita, Hara: "The histopathological comparison on the destruction of the periodontal tissue between normal junctional epithelium and long junctional epithelium." in: Journal of periodontal research, Vol. 52, Issue 1, pp. 74-82, (2016) (PubMed).

Nakatsu, Yoshinaga, Kuramoto, Nagano, Ichimura, Oshino, Yoshimura, Yano, Hara: "Occlusal trauma accelerates attachment loss at the onset of experimental periodontitis in rats." in: Journal of periodontal research, Vol. 49, Issue 3, pp. 314-22, (2014) (PubMed).

Nagano, Kaneko, Yoshinaga, Ukai, Kuramoto, Nakatsu, Oshino, Ichimura, Hara: "Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction." in: Journal of periodontal research, Vol. 48, Issue 4, pp. 420-7, (2013) (PubMed).

Kuramoto, Yoshinaga, Kaneko, Ukai, Shiraishi, Oshino, Ichimura, Hara: "The formation of immune complexes is involved in the acute phase of periodontal destruction in rats." in: Journal of periodontal research, Vol. 47, Issue 4, pp. 455-62, (2012) (PubMed).

Yoshinaga, Ukai, Kaneko, Nakatsu, Shiraishi, Kuramoto, Oshino, Ichimura, Hara: "Topical application of lipopolysaccharide into gingival sulcus promotes periodontal destruction in rats immunized with lipopolysaccharide." in: Journal of periodontal research, Vol. 47, Issue 5, pp. 674-80, (2012) (PubMed).

Target Details for C1QB

Target: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Alternative Name: C1QB

Background:

Targeted Subunit: B

Background Information: C1QB is a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. C1QB is the B-chain polypeptide of human complement subcomponent C1q.This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q.

Gene Name: Complement component 1, q subcomponent, B chain

Alternative Symbols: -

Protein Name: Complement C1q subcomponent subunit B

Molecular Weight: 27kDa

Gene ID: 713

NCBI Accession: NP_000482

UniProt: P02746

Pathways: Complement System