Inhibitor of Growth Family, Member 1 (ING1) antibody

Antigen: Inhibitor of Growth Family, Member 1 (ING1)

Synonyms: p33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a, p33ING1c, ING1, MGC136918, zgc:136918

Clonality: Polyclonal

Host: Rabbit

Reactivity: Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Dog (Canine), Zebrafish

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN311312

Additional Information

Alternative name: ING1

Gene ID: ING1

UniProt: Q5T9H0

Immunogen: The immunogen for anti-ING1 antibody: synthetic peptide directed towards the C terminal of human ING1

Sequence: EKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQ VSYGEMIGCD

Cross-Reactivity: Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)

Format: Lyophilized

Reconstitution: Add 100 µl of distilled water. Final anti-ING1 antibody concentration is 1 mg/ml.

Description: ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of ING1 gene have been detected in various cancers.This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Characteristics: Antigen Size: 279 amino acids

Molecular Weight: 32kDa

Application Details

Application Notes: WB Suggested Anti-ING1 Antibody Titration: 2.5ug/ml
Positive Control: HepG2 cell lysate.

Purification: Protein A purified

Buffer: PBS

Storage (Long Term): For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Storage (Short Term): Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.

Research Area: Cancer, Transcription Factors, Apoptosis/Necrosis

Restrictions: For Research Use only

Images

WB Suggested Anti-ING1 Antibody Titration: 2.5ug/ml
Positive Control: HepG2 cell lysate

Publications

Product: Ahmed, Kelly, Anderson et al.: "The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer." in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, Vol. 10, Issue 4, pp. 344-51, 2008 (PubMed).