ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
DT1P1B11 antibody, PHRIP antibody, TDAG51 antibody, Tdag antibody, pleckstrin homology like domain family A member 1 antibody, pleckstrin homology like domain, family A, member 1 antibody, pleckstrin homology-like domain, family A, member 1 antibody, pleckstrin homology-like domain, family A, member 1 L homeolog antibody, PHLDA1 antibody, Phlda1 antibody, phlda1.L antibody
Background
Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation. Thus, TDAG51 plays a critical role in T cell apoptosis by coupling TCR.Synonyms: Apoptosis-associated nuclear protein, PHRIP, PQ-rich protein, PQR protein, Pleckstrin homology-like domain family A member 1, Proline- and glutamine-rich protein, Proline- and histidine-rich protein, T-cell death-associated gene 51 protein