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Antibodies
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anti-Cholinergic Receptor, Muscarinic 1 (CHRM1) antibody
Cholinergic Receptor, Muscarinic 1 (CHRM1) antibody
| Antigen |
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| Synonyms |
M1, HM1, M1R, MGC30125, Chrm-1, mAChR, CHRM1, DKFZp459P0517 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Enzyme Immunoassay (EIA), Western Blotting (WB)
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| Catalog no. |
ABIN317696 |
| Quantity |
100 µg (1,0 mg/ml) (Variants) |
| Price |
340.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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Synonyms: CHRM1, mAChR M1, mAChR-M1
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Alternative name
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Muscarinic acetylcholine receptor M1
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Swiss-Prot
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P11229
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Cross-Reactivity
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Human, Mouse (Murine), Rat (Rattus)
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Description
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The muscarinic acetylcholine receptors (mAChR) mediate a variety of cellular responses,including inhibition of adenylate cyclase, breakdown of phosphoinositides andmodulation of potassium channels. The mAChRs transducer signals by coupling toG-proteins, which then modulate several downstream effector proteins and ion channels. Five mAChR subtypes have been identified, designated M1 to M5. The five receptorsubtypes show distinct patterns of tissue distribution, as well as distinct pharmacologicaland functional properties. The amino acid sequence of each mAChR subtype reflects a structure that is characteristicof G-protein coupled receptors, consisting of seven highly conserved transmembranesegments and a large intracellular region unique to each subtype, which constitutes theeffector-coupling domain.
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Specificity
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MAChR M1 antibody detects endogenous levels of mAChR M1 protein. Species: Human. Others not tested.
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Application Notes
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ELISA: 1: 5000~1: 20000. WB: 1: 500~1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Concentration
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1,0 mg/ml
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Purification
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Aff - Purified
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Buffer
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Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
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Storage
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Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Research Area
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Neurotransmitters, Hormones, Receptors
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Restrictions
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For Research Use only
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Alternatives for antigen "Cholinergic Receptor, Muscarinic 1 (CHRM1)", type "Antibodies"
