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Antibodies
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anti-Glutamate Receptor, Metabotropic 5 (GRM5) antibody
Glutamate Receptor, Metabotropic 5 (GRM5) antibody
| Antigen |
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| Synonyms |
mGlu5, GPRC1E, MGLUR5 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Enzyme Immunoassay (EIA), Western Blotting (WB)
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| Catalog no. |
ABIN317705 |
| Quantity |
100 µg (1,0 mg/ml) (Variants) |
| Price |
340.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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Synonyms: Metabotropic glutamate receptor 5, GPRC1E, MGLUR5
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Alternative name
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MGluR5 / GRM5
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Swiss-Prot
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P41594
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Cross-Reactivity
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Human, Mouse (Murine), Rat (Rattus)
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Description
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The mGluR proteins (metabotropic glutamate receptors) are members of the Gprotein-coupled receptor family and are functionally and pharmacologically distinct fromthe GluR proteins (ionotropic glutamate receptors). The eight currently known mGluRproteins are mediated by two G proteins with opposing regulation of adenylate cyclasepathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activatesa phosphatidylinositolcalcium second messenger system and generates acalcium-activated chloride current. The remainder of the eight subtypes of mGluR have anactivity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-3, whichmay interact with GRASP, acts as a receptor for glutamate.
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Specificity
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MGluR5 antibody detects endogenous levels of mGluR5 protein. Species: Human, Mouse, Rat. Others not tested.
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Application Notes
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ELISA: 1: 20000~1: 40000. WB: 1: 500~1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Concentration
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1,0 mg/ml
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Purification
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Aff - Purified
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Buffer
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Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
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Storage
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Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Restrictions
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For Research Use only
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Alternatives for antigen "Glutamate Receptor, Metabotropic 5 (GRM5)", type "Antibodies"
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Hosts
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Rabbit (18), Mouse (3)
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Reactivities
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Human (17), Rat (Rattus) (10), Mouse (Murine) (4), Rabbit (3), Dog (Canine) (1)
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Applications
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Western Blotting (WB) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Enzyme Immunoassay (EIA) (5), Immunoprecipitation (IP) (4), Flow Cytometry (FACS) (3), Immunofluorescence (IF) (3), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunohistochemistry (IHC) (2), ELISA (1), Immunocytochemistry (ICC) (1)
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Epitopes
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C-Term (2), AA 21-509 (1), C-Term T1003 (1)
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