Metabotropic Glutamate Receptor 5 antibody (AA 458-580)

Catalog No. ABIN5611178

This Mouse Monoclonal antibody specifically detects Metabotropic Glutamate Receptor 5 in IHC, ELISA and ICC. It exhibits reactivity toward Human.

Quick Overview for Metabotropic Glutamate Receptor 5 antibody (AA 458-580) (ABIN5611178)

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Metabotropic Glutamate Receptor 5 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Clone: 1A11D10

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody

Binding Specificity: AA 458-580

Purpose: GRM5 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human GRM5 (AA: 458-580) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Metabotropic Glutamate Receptor 5

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Alternative Name: GRM5

Background: This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.

Molecular Weight: 132.5 kDa

Gene ID: 2915

UniProt: P41594

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity