IP6K2 antibody

Catalog No. ABIN317720

Product Details anti-IP6K2 Antibody

Target: IP6K2 (Inositol Hexakisphosphate Kinase 2 (IP6K2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IP6K2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects endogenous levels of InsP6 kinase 2 / IP6K2 protein (region surrounding Leu188).

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity-chromatography

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 15 mM Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IP6K2

Target: IP6K2 (Inositol Hexakisphosphate Kinase 2 (IP6K2))

Alternative Name: InsP6 Kinase 2 / IP6K2 (IP6K2 Products)

Synonyms: IHPK2 antibody, ip6k2 antibody, ihpk2 antibody, cb1087 antibody, wu:fb47g07 antibody, wu:fi24d03 antibody, ihpk2b antibody, MGC69075 antibody, ihpk2a antibody, MGC84167 antibody, PIUS antibody, Ihpk2 antibody, Pius antibody, 1500005N04Rik antibody, AW050208 antibody, inositol hexakisphosphate kinase 2 antibody, inositol hexaphosphate kinase 2 antibody, inositol hexakisphosphate kinase 2a antibody, inositol hexaphosphate kinase 2 L homeolog antibody, inositol hexakisphosphate kinase 2b antibody, inositol hexaphosphate kinase 2 S homeolog antibody, IP6K2 antibody, ip6k2 antibody, ip6k2a antibody, ip6k2.L antibody, ip6k2b antibody, ip6k2.S antibody, MCYG_02913 antibody, Ip6k2 antibody

Background: The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors.Synonyms: IHPK2, Inositol hexakisphosphate kinase 2, P(i)-uptake stimulator, PiUS, TCCCIA00113

Molecular Weight: approx. 52 kDa

Gene ID: 51447

NCBI Accession: NP_001005909

UniProt: Q9UHH9