BMP8A antibody

Catalog No. ABIN317821

Product Details anti-BMP8A Antibody

Target: BMP8A (Bone Morphogenetic Protein 8A (BMP8A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP8A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: BMP-8A antibody detects endogenous levels of BMP-8A protein.(region surrounding Gln299)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/20000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BMP8A

Target: BMP8A (Bone Morphogenetic Protein 8A (BMP8A))

Alternative Name: BMP8A (BMP8A Products)

Synonyms: Bmp7r1 antibody, OP-2 antibody, OP2 antibody, bmp8 antibody, bone morphogenetic protein 8a antibody, Bmp8a antibody, BMP8A antibody, bmp8a antibody

Background: Bone morphogenic proteins (BMPs) are members of the TGFβ superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFβ receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 is thought to be involved in early development, as detectable expression has not been found in adult organs.Two BMP-8 proteins exist, namely BMP-8A and BMP-8B (also designated OP-2), and are encoded by two distinct genes.Synonyms: BMP-8A, Bone morphogenetic protein 8A

Molecular Weight: approx. 45 kDa

Gene ID: 353500

NCBI Accession: NP_861525

UniProt: Q7Z5Y6

Pathways: Negative Regulation of Hormone Secretion