GPRC5A antibody

Catalog No. ABIN317865

The Rabbit Polyclonal anti-GPRC5A antibody (ABIN317865) specifically detects GPRC5A in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GPRC5A antibody (ABIN317865)

Target: GPRC5A (G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPRC5A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GPRC5A Antibody

Specificity: RAI3 antibody detects endogenous levels of RAI3 protein.(region surrounding Leu179)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GPRC5A

Target: GPRC5A (G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A))

Alternative Name: GPRC5A / RAI3

Background: Retinoic acid-induced protein 3 (RAI3) is a transmembrane G protein-coupled receptor that affects many essential biological processes including embryogenesis,cell growth, differentiation and apoptosis. RAI3 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate RAI3 during its transcription in embryonal carcinoma differentiation. RAI3 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of RAI3 and represses its expression at the beginning of apoptosis. RAI3 is a potential molecular target for diagnosing breast cancer, selective suppression of signals from RAI3 may have a place in breast cancer treatments.Synonyms: G-protein coupled receptor C5A, GPCR5A, Orphan G-protein-coupling receptor PEIG-1, PEIG-1, RAIG1, Retinoic acid-induced gene 1 protein, Retinoic acid-induced protein 3

Molecular Weight: approx. 42 kDa

Gene ID: 9052

NCBI Accession: NP_003970

UniProt: Q8NFJ5