Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1) antibody

Antigen: Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1)

Synonyms: htpG

Clonality: Polyclonal

Host: Rabbit

Reactivity: Chicken

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Catalog no.: ABIN318867

Additional Information

Characteristics: Synonyms: HSP90A, HSPC1, HSPCA, Heat shock 86 kDa, HSP86, NY-REN-38, Heat shock protein HSP90-alpha

Alternative name: HSP90AA1 / HSP90 alpha

Swiss-Prot: P07900

Immunogen: Synthetic peptide corresponding to amino acids 289-300 of human heat shock protein 90alpha.

Cross-Reactivity: Chicken, Fruit Fly (Drosophila melanogaster), Human, Monkey, Mouse (Murine), Rat (Rattus)

Isotype: IgG  (Matching secondary antibodies)

Description: HSP90a is one of two HSP90 isoforms together with HSP90b. These isoforms are encodedby different genes and under normal conditions assist the folding of newly synthesisedproteins, and are also important in cellular processes such as hormone signalling and cellcycle control. In response to mutation or environmental stress, HSP90 expression isupregulated as part of the heat shock response, and function to maintain newlydestabilised proteins in a folding competent state. HSP90 can also affect the epigeneticstate at specific loci, leading to phenotype modulation. Induction of HSP90a by c-Myc maycontrol the activity of multiple signal pathways involved in cellular transformation.

Specificity: This antibody detects heat shock protein 90 alpha (HSP90a). Species: Human. Others not tested.

Application Details

Application Notes: ELISA: 1: 5000 - 1: 25000. Western Blot: 1: 500 - 1: 2500, detects a band of approximately 90kDa. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0mg/ml

Purification: Purified

Buffer: Phosphate buffered saline pH7.2 containing 0.09% Sodium Azide (NaN3)

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled bytrained staff only.

Restrictions: For Research Use only