DISC1 antibody (Middle Region)

Catalog No. ABIN318901

This Rabbit Polyclonal antibody specifically detects DISC1 in WB and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for DISC1 antibody (Middle Region) (ABIN318901)

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-DISC1 Antibody

Binding Specificity: Middle Region

Specificity: This antibody recognises disrupted in schizophrenia 1 (DISC1), 93 kDa protein located in the nucleus, cytoplasm and mitochondria.

Purification: Antisera to human DISC1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen: An 18 amino acid peptide located near the centre of human DISC1.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1 - 2g/mL, detects bands of approximately 95100 kDa in SKNSH cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for DISC1

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Alternative Name: DISC1

Background: The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B. In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1,11) (q42.1,q14.3) translocation, and studies suggest that DISC1 could be a candidate susceptibility gene for this condition.Synonyms: DISC-1, Disrupted in schizophrenia 1 protein, KIAA0457

Gene ID: 27185

NCBI Accession: NP_001012975

UniProt: Q9NRI5

Pathways: Regulation of Cell Size