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TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody

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Synonyms CARABIN, EPI64C, 1810062O14Rik, AI428527, RGD1311490
(16), (7), (5), (1)
Human, Mouse (Murine)
(35), (16), (5), (5), (3), (2), (1), (1)
(28), (8)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(30), (21), (13), (3), (2)
Pubmed 2 references available
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Quantity 0.1 mg
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Immunogen A 17 amino acid peptide from near the amino terminus of human Carabin.
Isotype IgG
Specificity This antibody recognises Carabin, also known as TBC1 domain family member 10C (TBC1D10C), a 50 kDa protein belonging to the TBC1 domain family of proteins. This antibody does not cross react with either TBC1D10A or TBC1D10B.
Purification Purified
Alternative Name Carabin (TBC1D10C Antibody Abstract)
Background Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Studies demonstrate that Carabin is part of a negative regulatory loop for the intracellular TCR signalling pathway and acts as an inhibitor of the Ras signalling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras. Carabin is most abundantly expressed in spleen and peripheral blood leucocytes.Synonyms: TBC1 domain family member 10C, TBC1D10C
Gene ID 374403
NCBI Accession NP_940919
UniProt Q8IV04
Application Notes Western Blot: 1 - 2g/mL, detects a band of approximately 55 kDa in human spleen tissuecell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)
Preservative Sodium azide
Precaution of Use This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
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 image for anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody (ABIN318913) anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody
 image for anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody (ABIN318913) anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody (Image 2)
Background publications Pan, Sun, Kardian et al.: "Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin." in: Nature, Vol. 445, Issue 7126, pp. 433-6, 2007 (PubMed).

White, Pasztor, Richardson et al.: "The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4." in: Cytogenetics and cell genetics, Vol. 89, Issue 3-4, pp. 272-5, 2000 (PubMed).

Catalog No. ABIN318913
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