LBP antibody

Catalog No. ABIN343175

Product Details anti-LBP Antibody

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LBP antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Human LBP (Lipopolysaccaride binding protein). The antibody don't block LPS binding to membrane bound CD14.

Cross-Reactivity: Cow (Bovine), Dog (Canine), Horse (Equine), Rabbit

Purification: Protein A affinity column

Immunogen: native human LBP

Clone: BiG42

Isotype: IgG1

Application Details

Application Notes: ELISA, Immune histology at paraffin sections, LBP inhibition studies, Western Blot. No inhibition of LPS binding to membrane bound CD14 Binding titre at human LBP- ELISA: 1:10.000

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with bidistilled water

Concentration: 1 mg/mL

Buffer: PBS, pH 7.12

Preservative: Without preservative

Storage: -20 °C,-80 °C

References for anti-LBP antibody (ABIN343175)

Eckert, Kim, Kim, Gürtler, Oh, Sur, Lundvall, Hamann, van der Ploeg, Pickkers, Giamarellos-Bourboulis, Kubarenko, Weber, Kabesch, Kumpf, An, Lee, Schumann: "The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity." in: Immunity, Vol. 39, Issue 4, pp. 647-60, (2013) (PubMed).

Rahman, Lecchi, Avallone, Roccabianca, Sartorelli, Ceciliani: "Lipopolysaccharide-binding protein: Local expression in bovine extrahepatic tissues." in: Veterinary immunology and immunopathology, (2010) (PubMed).

Ren, Jin, Leung: "Local expression of lipopolysaccharide-binding protein in human gingival tissues." in: Journal of periodontal research, Vol. 39, Issue 4, pp. 242-8, (2004) (PubMed).

Target Details for LBP

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Alternative Name: Lipopolysaccharide (LPS)-Binding Protein (LBP) (LBP Products)

Synonyms: BPIFD2 antibody, Bpifd2 antibody, Ly88 antibody, LPSBP antibody, LBP antibody, lipopolysaccharide binding protein antibody, lipopolysaccharide-binding protein antibody, LBP antibody, Lbp antibody, LOC100472839 antibody

Background: Background: Natural Lipopolysccaride Binding Protein (LBP) is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.

Molecular Weight: ~58kDa

Gene ID: 3929

NCBI Accession: NP_004130

UniProt: P18428

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process