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Details for Product No. ABIN349989

ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae) (ATG4C) antibody

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Antigen
Synonyms APG4-C, APG4C, AUTL1, AUTL3, Apg4-C, Apg4c, Atg4cl, Autl1, apg4c, atg4cl, zgc:86888, wu:fc56g07
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN349989
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from human cysteine protease ATG4C (autophagin-3, APG4C, AUTL1, AUTL3) conjugated to an immunogenic carrier protein has been used as the immunogen. The antigen is homologous in rat and mouse.
Isotype IgG
Specificity Appears to be specific for ATG4C.
Purity IgG
Alternative Name cysteine protease ATG4C (autophagin-3, APG4C, AUTL1, AUTL3)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. Cysteine protease required forautophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Enzyme regulation: Inhibited by N-ethylmaleimide.
Tissue specificity: Highly expressed in skeletal muscle, heart, liver and testis. Also known as: ATG4C, autophagin-3, APG4C, AUTL1, AUTL3, APG4-C, FLJ14867, ATG4autophagy related 4 homolog C (S. cerevisiae),autophagy-related protein 4 homolog C,autophagy-related cysteine endopeptidase 3, AUT-like 3 cysteine endopeptidase.
UniProt Q96DT6
Research Area Autophagy
Application Notes IHC, WB. Use at a concentration of 10-50 µg/ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Mariño, Uría, Puente et al.: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).

Alternatives for antigen "ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae) (ATG4C)", type "Antibodies"
Hosts (87), (5), (3), (1)
Reactivities (82), (72), (66), (48), (48), (48)
Applications (50), (44), (30), (18), (14), (10), (5), (3), (2), (1), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (12), (12), (12), (12), (3), (2), (2), (2), (2), (1), (1)
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