Activity-Regulated Cytoskeleton-Associated Protein (Arc) (Arg3) antibody

Details for Product No. ABIN350080
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Synonyms Arg3.1, rg3.1, ARG3.1, ARC, arg3.1
(5), (3), (1)
Human, Mouse (Murine), Rat (Rattus)
(8), (5), (3), (1)
(10), (2), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(12), (7), (6), (6), (4), (4), (1), (1), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN350080
Quantity 500 µg
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from human Arg3.1 (ARC) was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for VACHT.
Purification IgG
Alternative Name Arg3.1 (ARC)
Background Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
Subcellular location: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail. Also known as: Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, Arg3.1/ARC,.
UniProt Q62666
Application Notes Use at a concentration of 10-50 µg/mL.
The optimal working concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
General Chowdhury, Shepherd, Okuno et al.: "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking." in: Neuron, Vol. 52, Issue 3, pp. 445-59, 2006 (PubMed).

Rial Verde, Lee-Osbourne, Worley et al.: "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission." in: Neuron, Vol. 52, Issue 3, pp. 461-74, 2006 (PubMed).

Shepherd, Rumbaugh, Wu et al.: "Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors." in: Neuron, Vol. 52, Issue 3, pp. 475-84, 2006 (PubMed).

Tan, Ruettiger, Panford-Walsh et al.: "Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma." in: Neuroscience, Vol. 145, Issue 2, pp. 715-26, 2007 (PubMed).

Hosts (10), (2), (1), (1)
Reactivities (8), (5), (3), (1)
Applications (12), (7), (6), (6), (4), (4), (1), (1), (1), (1), (1)
Epitopes (5), (3), (1)
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