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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Cache Domain Containing 1 (CACHD1) (C-Term) antibody
|Synonyms||KIAA1573, RP4-655E10.1, RGD1310770, Vwcd1, AI852726, mKIAA1573, RP23-29O24.1, 1190007F10Rik, B430218L07Rik, CACHD1|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|4 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from the c-terminal region of CACHD1 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is identical in mouse.|
|Description||FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Defects in CACNA2D4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity. Tissue specificity: Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophiles of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level). Subcellular location: Membrane; Single-pass type I membrane protein Miscellaneous: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. Also known as: VWFA and cache domain-containing protein 1, Cache domain-containing protein 1.|
|Specificity||Appears to be specific for CACHD1.|
|Application Notes||IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Nagase, Kikuno, Nakayama et al.: "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 4, pp. 273-81, 2000 (PubMed).
Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).
Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).
|Reactivities||Human (3), Mouse (Murine) (1), Rat (Rattus) (1)|
|Applications||Western Blotting (WB) (5), ELISA (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunohistochemistry (IHC) (1), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1)|
|Epitopes||C-Term (2), N-Term (1)|