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SOD3 antibody (Superoxide Dismutase 3, Extracellular) (N-Term)

Details for Product anti-SOD3 Antibody No. ABIN350844, Supplier: Log in to see
Antigen
  • AI314465
  • EC-SOD
  • ECSOD
  • ECSODPT
  • fb05f10
  • LOC780439
  • si:dkey-117m1.6
  • sod3
  • SOD3
  • SODA.4
  • wu:fb05f10
Epitope
N-Term
38
19
10
10
7
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
115
63
42
18
2
Host
Rabbit
82
55
4
2
1
Clonality
Polyclonal
Conjugate
This SOD3 antibody is un-conjugated
11
6
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
119
83
62
61
40
13
10
8
5
4
3
1
Supplier
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Immunogen A synthetic peptide from the n-terminal region of human SOD3 conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Specific for SOD3.
Alternative Name SOD3 (SOD3 Antibody Abstract)
Background Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Catalytic activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
Tissue specificity: Expressed in blood vessels, heart, lungs, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
Subcellular location: Secreted › extracellular space. Note: 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium. Also known as: Superoxide dismutase 3, SODE, SOD E.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Nozik-Grayck, Suliman, Piantadosi: "Extracellular superoxide dismutase." in: The international journal of biochemistry & cell biology, Vol. 37, Issue 12, pp. 2466-71, 2005

Adachi, Morihara, Yamazaki, Yamada, Futenma, Kato, Hirano: "An arginine-213 to glycine mutation in human extracellular-superoxide dismutase reduces susceptibility to trypsin-like proteinases." in: Journal of biochemistry, Vol. 120, Issue 1, pp. 184-8, 1997

Folz, Crapo: "Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene." in: Genomics, Vol. 22, Issue 1, pp. 162-71, 1994

Adachi, Ohta, Hayashi, Hirano, Marklund: "The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro." in: Free radical biology & medicine, Vol. 13, Issue 3, pp. 205-10, 1992

Hjalmarsson, Marklund, Engström, Edlund: "Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 18, pp. 6340-4, 1987