Synaptotagmin I (SYT1) antibody

Details for Product No. ABIN350918
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Antigen
Synonyms
CG3139, D. Syt I, DSYT, DSYT2, DSypt, DSyt, Dmel\\CG3139, Droso1, Dsyt2, SYT, SYT I, SYT1, Syt, Syt 1, Syt I, Syt-1, SytI, dSYT, dsyt1, dsytI, l(2)23AB1, l(2)23Ba, l(2)k05909, syt, syt 1, syt I, syt-1 ... show more
CG3139, D. Syt I, DSYT, DSYT2, DSypt, DSyt, Dmel\\CG3139, Droso1, Dsyt2, SYT, SYT I, SYT1, Syt, Syt 1, Syt I, Syt-1, SytI, dSYT, dsyt1, dsytI, l(2)23AB1, l(2)23Ba, l(2)k05909, syt, syt 1, syt I, syt-1, syt1, sytI, Syti, GB20036, svp65, DKFZP459P193, 5430411C10Rik, GOLPH5, GRASP65, P65, SVP65, AW124717, G630098F17Rik, p65 show less
Reactivity
Tag
(132), (85), (72), (45), (42), (41), (36), (7), (3), (2), (2)
Host
Sheep
(117), (31), (6), (5), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (6), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(123), (48), (44), (30), (22), (20), (19), (8)
Pubmed 1 reference available
Quantity 500 μg
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Catalog No. ABIN350918
454.67 $
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Immunogen A synthetic peptide from human Synaptotagmin-1 (Synaptotagmin I) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Specific for Synaptotagmin-1.
Alternative Name Synaptotagmin-1
Background Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner, these are neurexins, syntaxin and AP2.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note: Synaptic vesicles and chromaffin granules.
Tissue specificity: Predominantly expressed in rostral, phylogenetically younger brain regions, and in some endocrine tissues. Also known as: Synaptotagmin-1, Synaptotagmin I, SytI, p65, SVP65.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Perin, Fried, Mignery et al.: "Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C." in: Nature, Vol. 345, Issue 6272, pp. 260-3, 1990 (PubMed).

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