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Thyroglobulin antibody (TG) (AA 310-360)

Details for Product anti-TG Antibody No. ABIN351006, Supplier: Log in to see
Antigen
  • AITD3
  • cb717
  • cog
  • TG
  • TGN
  • Tgn
Epitope
AA 310-360
42
5
5
4
3
3
2
2
2
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine), Human
520
186
179
23
22
20
19
1
1
1
Host
Sheep
457
57
7
4
1
Clonality
Polyclonal
Conjugate
This Thyroglobulin antibody is un-conjugated
19
14
13
12
10
10
10
10
10
10
10
10
10
10
10
10
10
10
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
251
198
190
128
113
26
14
9
9
6
5
4
3
3
2
2
2
2
2
2
1
1
1
Supplier
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Immunogen A synthetic peptide from aa region 310-360 of mouse TGN38 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human.
Isotype IgG
Specificity Specific for TGN38.
Alternative Name TGN (TG Antibody Abstract)
Background Function: May be involved in regulating membrane traffic to and from trans-Golgi network.
Subcellular location: Cell membrane, Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane, Single-pass type I membrane protein. Note: Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.
Tissue specificity: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.
Miscellaneous: Not found in strains BALB/c, C57BL/6 and DBA/2. Also known as: Trans-Golgi network protein TGN51, TGN46, TGN48, TGN38 homolog, Trans-Golgi network integral membrane protein 2, TGOLN2.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Dai, Jin, Sheng, Shieh, Wu, Zeng: "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." in: Journal of proteome research, Vol. 6, Issue 1, pp. 250-62, 2007 (PubMed).

Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Wu, MacCoss, Mardones, Finnigan, Mogelsvang, Yates, Howell: "Organellar proteomics reveals Golgi arginine dimethylation." in: Molecular biology of the cell, Vol. 15, Issue 6, pp. 2907-19, 2004 (PubMed).

Kasai, Takahashi, Murakami, Nakayama: "Strain-specific presence of two TGN38 isoforms and absence of TGN41 in mouse." in: The Journal of biological chemistry, Vol. 270, Issue 24, pp. 14471-6, 1995 (PubMed).