Fibrillin 1 antibody

Catalog No. ABIN356183

Product Details anti-Fibrillin 1 Antibody

Target: Fibrillin 1 (FBN1)

Reactivity: Human, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fibrillin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunoelectron Microscopy (IEM)

Specificity: This antibody recognises Fibrillin (Mr 350 kDa).

Characteristics: Synonyms: FBN1, FBN

Purification: Purified

Immunogen: Microfibrils from zonular apparatus of bovine eye.

Clone: 11C1-3

Isotype: IgG1

Application Details

Application Notes: Immunohistochemistry: 1/50-1/100 (30-60 min at RT). (See Ref.2)Immunofluorescence. (See Ref.2)Western blotting: < / = 1 μg/mL (See Ref.2)Electron Microscopic Immunolocalization. (See Ref.2)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for Fibrillin 1

Target: Fibrillin 1 (FBN1)

Alternative Name: Fibrillin-1 (FBN1 Products)

Synonyms: FBN1 antibody, ACMICD antibody, ECTOL1 antibody, FBN antibody, GPHYSD2 antibody, MASS antibody, MFS1 antibody, OCTD antibody, SGS antibody, SSKS antibody, WMS antibody, WMS2 antibody, AI536462 antibody, B430209H23 antibody, Fib-1 antibody, Tsk antibody, fibrillin 1 antibody, FBN1 antibody, Fbn1 antibody

Background: The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12 nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear.(Ref.1) In Immunohistochemical staining of paraformaldehyde-fixed human skin, mAb 11C1.3 labels the elastic framework and more specifically the oxytalantic network close to the epidermis. The antibody also exhibits discrete staining of normal fibroblasts in culture and of extracellular (elastin) fibrils in a variety of tissues.(Ref.2,3) There is an aberrant expression of fibrillin in Marfan syndrome.(Ref.4)Synonyms: FBN, FBN1

Gene ID: 2200

UniProt: P35555

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interactome