Histone Deacetylase 7 (HDAC7) (C-Term) antibody

Details for Product No. ABIN356651
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Antigen
Synonyms hdac7a, HD7A, HDAC7A, 5830434K02Rik, HD7, HD7a, Hdac7a, mFLJ00062, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR, K2K18.5, K2K18_5, histone deacetylase7
Epitope
C-Term
(21), (21), (19), (12), (12), (8), (7), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(150), (91), (75), (36), (24), (24), (1), (1)
Host
Rabbit
(143), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (8), (8), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3)
Application
Western Blotting (WB), ELISA
(112), (68), (40), (33), (22), (14), (10), (8), (3), (3), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN356651
357.50 $
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Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of human HDAC7
Specificity This antibody is specific to Human HDAC7 (C-term).
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name HDAC7
Background Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C- terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
Alternate names: HD7, HD7a, HDAC7A, Histone deacetylase 7
Gene ID 51564, 5874
UniProt Q8WUI4
Research Area Cardiovascular, Hypertrophy, Wnt, DNA/RNA, Transcription Factors
Application Notes ELISA: 1/1,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Histone Deacetylase 7 (HDAC7) (C-Term) antibody anti-Histone Deacetylase 7 (HDAC7) (C-Term) antibody
Background publications Cress, Seto: "Histone deacetylases, transcriptional control, and cancer." in: Journal of cellular physiology, Vol. 184, Issue 1, pp. 1-16, 2000 (PubMed).

Meinke, Liberator: "Histone deacetylase: a target for antiproliferative and antiprotozoal agents." in: Current medicinal chemistry, Vol. 8, Issue 2, pp. 211-35, 2001 (PubMed).

Nakayama, Takami: "Participation of histones and histone-modifying enzymes in cell functions through alterations in chromatin structure." in: Journal of biochemistry, Vol. 129, Issue 4, pp. 491-9, 2001 (PubMed).

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