GGPS1 antibody (N-Term)

Catalog No. ABIN357715

Product Details anti-GGPS1 Antibody

Target: GGPS1 (Geranylgeranyl Diphosphate Synthase 1 (GGPS1))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GGPS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects GGPS1 (N-term).

Purification: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human GGPS1.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for GGPS1

Target: GGPS1 (Geranylgeranyl Diphosphate Synthase 1 (GGPS1))

Alternative Name: GGPP Synthetase (GGPS1 Products)

Synonyms: geranylgeranyl pyrophosphate synthase 1 antibody, DDBDRAFT_0192027 antibody, DDBDRAFT_0233098 antibody, DDB_0192027 antibody, DDB_0233098 antibody, GGPPS antibody, GGPPS1 antibody, 1810026C22Rik antibody, 9530089B04Rik antibody, AI843169 antibody, C79210 antibody, Crlf3 antibody, rGGPS1a antibody, rGGPS1a1 antibody, rGGPS1a2 antibody, rGGPS1a3 antibody, fb05f09 antibody, qm antibody, wu:fb05f09 antibody, zgc:101591 antibody, zgc:56514 antibody, geranylgeranyl pyrophosphate synthase 1 antibody, geranylgeranyl pyrophosphate synthetase antibody, geranyl pyrophosphate synthase antibody, geranylgeranyl pyrophosphate synthase,chloroplastic antibody, geranylgeranyl diphosphate synthase 1 antibody, geranylgeranyl diphosphate synthase 1 L homeolog antibody, GGPS1 antibody, gGPS1 antibody, ggps1 antibody, Ggps1 antibody, ggps1.L antibody

Background: Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300-amino acid human protein contains 5 conserved domains consistent with prenyltransferases. Recombinant GGPS shows enzymatic properties associated with the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Mouse GGPS is regulated in several tissues in obesity and is induced during adipocyte differentiation. GGPS is increased 5- to 20-fold in skeletal muscle, liver, and fat of ob/ob mice. Western blot analysis detects a 2-fold overexpression of protein in muscle and fat but not in liver. Differentiation of mouse fibroblasts into adipocytes induces GGPS expression more than 20-fold.Synonyms: GGPPSase, GGPS1, Geranylgeranyl pyrophosphate synthetase

Molecular Weight: 34871 Da

Gene ID: 9453, 5874

UniProt: O95749