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Collagen Type IX (Chain alpha 1) antibody

Details for Product No. ABIN357919
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Antigen
Epitope
Chain alpha 1
(1)
Reactivity
Human
(5), (3), (1), (1), (1)
Host
Rabbit
(6), (2)
Clonality
Polyclonal
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(6), (6), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN357919
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human COL9A1.
Specificity This antibody detects COL9A1 (Center). Predicted to cross react with Mouse (100% Antigen Homology).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background COL9A1 is one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule,and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in the COL9A1 gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects.
Alternate names: COL9A1
Molecular Weight 91855 Da
Gene ID 1297
NCBI Accession 9606
UniProt P20849
Research Area Extracellular Matrix
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100. Immunohistochemistry: 1/10-1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Collagen Type IX (Chain alpha 1) antibody anti-Collagen Type IX (Chain alpha 1) antibody
anti-Collagen Type IX (Chain alpha 1) antibody (2) anti-Collagen Type IX (Chain alpha 1) antibody (Image 2)
Background publications Sivakumaran, Resendes, Robertson et al.: "Characterization of an abundant COL9A1 transcript in the cochlea with a novel 3' UTR: Expression studies and detection of miRNA target sequence." in: Journal of the Association for Research in Otolaryngology : JARO, Vol. 7, Issue 2, pp. 160-72, 2006 (PubMed).

Van Camp, Snoeckx, Hilgert et al.: "A new autosomal recessive form of Stickler syndrome is caused by a mutation in the COL9A1 gene." in: American journal of human genetics, Vol. 79, Issue 3, pp. 449-57, 2006 (PubMed).

Liu, Jin, Cao et al.: "[Analysis of association between COL9A1 gene and idiopathic congenital talipes equinovarus]." in: Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji, Vol. 29, Issue 4, pp. 427-32, 2007 (PubMed).

Fresquet, Jowitt, Ylöstalo et al.: "Structural and functional characterization of recombinant matrilin-3 A-domain and implications for human genetic bone diseases." in: The Journal of biological chemistry, Vol. 282, Issue 48, pp. 34634-43, 2007 (PubMed).

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