DTYMK antibody (C-Term)

Catalog No. ABIN359136

Product Details anti-DTYMK Antibody

Target: DTYMK (Deoxythymidylate Kinase (Thymidylate Kinase) (DTYMK))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DTYMK antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to DTYMK.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DTYMK.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1/1,000. Western blotting: 1/100 - 1/500. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for DTYMK

Target: DTYMK (Deoxythymidylate Kinase (Thymidylate Kinase) (DTYMK))

Alternative Name: Thymidylate Kinase (DTYMK Products)

Synonyms: tymk antibody, wu:fa12c02 antibody, wu:fb14h07 antibody, wu:ft84f02 antibody, zgc:123174 antibody, DTYMK antibody, MGC81047 antibody, Tb08.28L1.680 antibody, Tb08.10J17.310 antibody, DDBDRAFT_0188698 antibody, DDBDRAFT_0230101 antibody, DDB_0188698 antibody, DDB_0230101 antibody, AU044245 antibody, CDC8 antibody, D10Ertd203e antibody, TMPK antibody, TYPK antibody, Tmk antibody, mtmk antibody, PP3731 antibody, TYMK antibody, deoxythymidylate kinase antibody, deoxythymidylate kinase (thymidylate kinase) antibody, deoxythymidylate kinase S homeolog antibody, thymidylate kinase antibody, dTMP kinase antibody, Dtymk antibody, dtymk antibody, DTYMK antibody, dtymk.S antibody, Tmk antibody, CNC04630 antibody, Tb927.8.3510 antibody, Tb927.8.3910 antibody, Ndas_4954 antibody, Mesil_2461 antibody, Slip_0046 antibody, Trad_0568 antibody, Olsu_1446 antibody, Acear_0042 antibody, Igag_1070 antibody, LOC100195817 antibody

Background: Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.Synonyms: CDC8, DTYMK, TMPK, TYMK, dTMP kinase

Gene ID: 1841, 9606

UniProt: P23919

Pathways: Nucleotide Phosphorylation