Mitogen-Activated Protein Kinase 4 (MAPK4) (N-Term) antibody

Details for Product No. ABIN359555
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Antigen
Synonyms ERK-4, ERK3, Erk4, MAPK 4, PRKM4, p63MAPK, A330097D03Rik, Erk3, Prkm4, p63Mapk, erk4, wu:fi27d11, zgc:55498, ATMPK4, F2N1.1, F2N1_1, MAP kinase 4
Epitope
N-Term
(21), (10), (7), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(44), (22), (14), (1), (1), (1), (1), (1)
Host
Rabbit
(43), (5), (2), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(40), (19), (16), (11), (10), (6), (4), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Request Want additional data for this product?

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Catalog No. ABIN359555
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human NAPK4.
Specificity This antibody reacts to MAPK4.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name MAPK4 / ERK4
Background Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.
Alternate names: Extracellular signal-regulated kinase 4, MAP kinase isoform p63, Mitogen-activated protein kinase 4, p63-MAPK
Gene ID 5596
NCBI Accession NP_002738
UniProt P31152
Application Notes ELISA: 1/1,000. Immunohistochemistry: 1/10 - 1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Seger, Krebs: "The MAPK signaling cascade." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 9, Issue 9, pp. 726-35, 1995 (PubMed).

Kant, Schumacher, Singh et al.: "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5." in: The Journal of biological chemistry, Vol. 281, Issue 46, pp. 35511-9, 2006 (PubMed).

Lerner-Marmarosh, Miralem, Gibbs et al.: "Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 19, pp. 6870-5, 2008 (PubMed).

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