ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) (C-Term) antibody

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Synonyms EST170205, MOAT-B, MOATB, MRP4, D630049P08Rik, Mrp4
(24), (20), (9), (8), (7), (6), (4), (2), (2), (1), (1), (1)
(96), (36), (28), (1), (1), (1), (1)
(41), (40), (16), (10)
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(85), (54), (36), (18), (15), (10), (9), (9), (6), (3), (2), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ABCC4.
Isotype Ig
Specificity This antibody reacts to ABCC4.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name ABCC4 / MRP4 (ABCC4 Antibody Abstract)
Background ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined, however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.Synonyms: ATP-binding cassette sub-family C member 4, MOAT-B, MRP/cMOAT-related ABC transporter, Multi-specific organic anion transporter B, Multidrug resistance-associated protein 4
Gene ID 10257, 9606
UniProt O15439
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) (C-Term) antibody (ABIN359599) Western blot analysis of anti-ABCC4 Antibody (C-term) in CEM cell line lysates (35ug/...
Background publications Janke, Mehralivand, Strand et al.: "6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4." in: Human mutation, Vol. 29, Issue 5, pp. 659-69, 2008 (PubMed).

Adachi, Sampath, Lan et al.: "Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38998-9004, 2002 (PubMed).

Lee, Belinsky, Bell et al.: "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter." in: Cancer research, Vol. 58, Issue 13, pp. 2741-7, 1998 (PubMed).

Kool, de Haas, Scheffer et al.: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).

Catalog No. ABIN359599
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