Chloride Intracellular Channel 4 (CLIC4) antibody

Details for Product No. ABIN359726
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Antigen
Synonyms clic4, MGC89006, MGC79614, CLIC4, DKFZp459A0325, xclic4, CLIC4L, H1, MTCLIC, huH1, p64H1, cb142, wu:fb33c05, wu:fc30h10, D0Jmb3, TU-74, mc3s5, mtCLIC
Reactivity
Human
(57), (36), (36), (17), (13), (11), (11), (1), (1), (1)
Host
Rabbit
(55), (8), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(56), (38), (21), (21), (9), (8), (8), (6), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN359726
357.50 $
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Immunogen This antibody is generated from rabbits immunized with recombinant human CLIC4 protein.
Isotype Ig
Specificity This antibody reacts to CLIC4.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name CLIC4
Background Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH , and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family, the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).Synonyms: Chloride Intracellular Channel Protein 4, Intracellular Chloride Ion Channel Protein p64H1, mc3s5, mtCLIC, p64H1
Gene ID 25932, 9606
UniProt Q9Y696
Research Area Signaling, Metabolism, Cell Cycle, Apoptosis/Necrosis
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Hales, Luzio, Chandler et al.: "Localization of calcium in the smooth endoplasmic reticulum of rat isolated fat cells." in: Journal of cell science, Vol. 15, Issue 1, pp. 1-15, 1974 (PubMed).

Suh, Crutchley, Koochek et al.: "Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 1, pp. 121-31, 2007 (PubMed).

Singh, Cousin, Ashley: "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin." in: The FEBS journal, Vol. 274, Issue 24, pp. 6306-16, 2007 (PubMed).

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