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Details for Product No. ABIN359726

Chloride Intracellular Channel 4 (CLIC4) antibody

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Antigen
Synonyms CLIC4L, H1, MTCLIC, huH1, p64H1, cb142, wu:fb33c05, wu:fc30h10, D0Jmb3, TU-74, mc3s5, mtCLIC, xclic4, clic4, MGC89006, MGC79614, CLIC4, DKFZp459A0325
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN359726
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with recombinant human CLIC4 protein.
Specificity This antibody reacts to CLIC4.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name CLIC4
Background Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family, the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).
Alternate names: Chloride Intracellular Channel Protein 4, Intracellular Chloride Ion Channel Protein p64H1, mc3s5, mtCLIC, p64H1
Gene ID 25932
NCBI Accession 9606
UniProt Q9Y696
Research Area Signaling, Metabolism, Cell Cycle, Apoptosis/Necrosis
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Hales, Luzio, Chandler et al.: "Localization of calcium in the smooth endoplasmic reticulum of rat isolated fat cells." in: Journal of cell science, Vol. 15, Issue 1, pp. 1-15, 1974 (PubMed).

Suh, Crutchley, Koochek et al.: "Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 1, pp. 121-31, 2007 (PubMed).

Singh, Cousin, Ashley: "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin." in: The FEBS journal, Vol. 274, Issue 24, pp. 6306-16, 2007 (PubMed).

Alternatives for antigen "Chloride Intracellular Channel 4 (CLIC4)", type "Antibodies"
Hosts (48), (8), (4)
Reactivities (47), (31), (30), (16), (12), (11), (11), (1), (1), (1)
Applications (50), (36), (19), (18), (9), (9), (6), (6)
Conjugates (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (6)
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