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PD-1 antibody
PDCD1
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
4F12
unconjugated
Product Details anti-PD-1 Antibody
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Target
See all PD-1 (PDCD1) Antibodies
PD-1 (PDCD1)
(Programmed Cell Death 1 (PDCD1))
Reactivity
All reactivities for PD-1 antibodies
Human
Host
All hosts for PD-1 antibodies
Mouse
Clonality
All clonalities for PD-1 antibodies
Monoclonal
Conjugate
All conjugates for PD-1 antibodies
This PD-1 antibody is un-conjugated
Application
All applications for PD-1 antibodies
Western Blotting (WB), ELISA
Purification
The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography
Immunogen
Recombinant human PDCD1 (21-167aa) , Accession / GI number: AAH74740
Clone
4F12
Isotype
IgG2b kappa
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Discover our top product PDCD1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Recommended dilution 1:500
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1mg/ml
Buffer
In Phosphate-Buffered Saline (pH7.4) with 0.1% Sodium Azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Target Details for PD-1
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Target
PD-1 (PDCD1)
(Programmed Cell Death 1 (PDCD1))
Alternative Name
PDCD1 (PDCD1 Products )
Synonyms
CD279 antibody, PD-1 antibody, PD1 antibody, SLEB2 antibody, hPD-1 antibody, hPD-l antibody, Ly101 antibody, Pdc1 antibody, programmed cell death 1 antibody, PDCD1 antibody, Pdcd1 antibody
Background
PDCD1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily, also known as Programmed Cell Death 1. It is expressed on activated T cell, B cells, myeloid cells and a subset of thymocytes. PDCD1 interacts with expressed PDL1 and PDL2 to inhibit the proliferation and activation of T cells and B cells. Both PDL1 and PDL2 are expressed in a wide variety of normal tissues including heart, lung, placenta, spleen and kidney. PDCD1 might be involved in the regulation of peripheral tolerance and may help prevent autoimmune diseases
Pathways
Cancer Immune Checkpoints
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