Thyroid Hormone Receptor, alpha 2 (THRA) antibody

Antigen: Thyroid Hormone Receptor, alpha 2 (THRA)

Clonality: Monoclonal (1330)

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN361384

Additional Information

Alternative name: Thyroid Hormone Receptor, a2-Isotype

Format: Affinity-purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: 1330

Description: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors, TRa1, TRa2, TRß1 and TRß2. TRa1, TRß1 and TRß2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). Anti-Human Thyroid Hormone Receptor, a2-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~58k TR-a2 protein.

Specificity: Specific for the ~58k TR-a2 protein.

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Purification: Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.

Storage: Store at -20 °C, stable for 1 year

Restrictions: For Research Use only

Images

Western blots of hippocampal lysate showing specific immunolabeling of the ~58k TR-a2 protein.