Choline O-Acetyltransferase (CHAT) antibody

Antigen: Choline O-Acetyltransferase (CHAT)

Synonyms: CMS1A, CMS1A2, B230380D24Rik, CT23399, Cat, ChAT, cha, dChAT, l(3)91Cc, DmelCG12345, CG12345, CHAT, ChoAcTase, Ci-ChAT

Clonality: Polyclonal

Host: Rabbit

Reactivity: Chicken, Guinea Pig, Human, Mouse (Murine), Primates, Rat (Rattus)

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Catalog no.: ABIN361420

Additional Information

Alternative name: Choline Acetyltransferase

Description: Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999). .Anti-Choline Acetyltransferase Western blot of rat brain lysate showing specific immunolabeling of the ~68/70k ChAT

Specificity: Specific for the ~ 68/70 k choline acetyltransferase protein

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 IHC: 1:100 Quality Control: Western blots performed on each lot.

Purification: Neat serum

Storage: Store at -20 °C, stable for 1 year

Research Area: Neurology

Restrictions: For Research Use only

Images

Western blots of rat brain lysate showing specific immunolabeling of the ~68/70k ChAT Antibody Specificity: Specific for the ~ 68/70 k choline acetyltransferase protein