Histone Deacetylase 4 (HDAC4) (pSer632) antibody

Details for Product No. ABIN362215
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Antigen
Synonyms
AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, AI047285, 4932408F19Rik, wu:fa96d08, wu:fc56f08, zgc:152701, CG1770, DHDAC4, Dmel\\CG1770, GC1770, HDAC, HDAC4a, dHDAC4, dmHDA405, hdac4, dana_GLEANR_19 ... show more
AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, AI047285, 4932408F19Rik, wu:fa96d08, wu:fc56f08, zgc:152701, CG1770, DHDAC4, Dmel\\CG1770, GC1770, HDAC, HDAC4a, dHDAC4, dmHDA405, hdac4, dana_GLEANR_19966, DanaGF18710, GF18710, HDAC4 show less
Epitope
pSer632
(37), (17), (13), (9), (6), (6), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(171), (101), (76), (35), (24), (24), (1), (1), (1), (1)
Host
Rabbit
(159), (21), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(152), (51), (35), (30), (24), (21), (14), (11), (7), (4), (3), (1), (1)
Pubmed 2 references available
Catalog no. ABIN362215
Quantity 50 µL
Price
198.00 $   Plus shipping costs $45.00
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Immunogen Peptide sequence around phosphorylation site of pSer632 (A-Q-S (p) -S-P) derived from Human HDAC4. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of HDAC4 only when phosphorylated at serine 632.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name HDAC4
Background Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Molecular Weight 140 kDa
NCBI Accession NP_006028
UniProt P56524
Research Area Cardiovascular, Hypertrophy, Wnt, DNA/RNA, Transcription Factors
Application Notes Western blotting: 1:500-1:1000  
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Grozinger, Schreiber: "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 14, pp. 7835-40, 2000 (PubMed).

Wang, Kruhlak, Wu et al.: "Regulation of histone deacetylase 4 by binding of 14-3-3 proteins." in: Molecular and cellular biology, Vol. 20, Issue 18, pp. 6904-12, 2000 (PubMed).

Hosts (159), (21), (1)
Reactivities (171), (101), (76), (35), (24), (24), (1), (1), (1), (1)
Applications (152), (51), (35), (30), (24), (21), (14), (11), (7), (4), (3), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (37), (17), (13), (9), (6), (6), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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