Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody

Details for Product No. ABIN371199
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Antigen
Synonyms LAMPA, CD107a, LGP120, AI196048, Lamp-1, LEP100
Reactivity
Mouse (Murine)
(123), (70), (41), (8), (7), (5), (3), (2)
Host
Rat
(76), (63), (30), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(19), (14), (13), (9), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB), Immunoelectron Microscopy (IEM), Flow Cytometry (FACS)
(86), (81), (32), (28), (27), (26), (24), (22), (19), (10), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN371199
Quantity 0.5 mg
Price
324.50 $   Plus shipping costs $45.00
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Immunogen Plasma membrane fraction of mouse embryo NIH3T3 cell line. (Ref. 1)
Clone 1D4B
Isotype IgG2a
Characteristics Synonyms: LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1, CD107Antigen-like Family Member A
Purification Purified
Alternative Name CD107a / LAMP1
Background CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavilyglycosylated, type I transmembrane protein that constitutes one of the two majorsialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomesfrom other organelles. (Ref. 1) It is a ligand for galaptin, an S-type lectin present inextracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains,and is a ligand for E-selectin-mediated cell adhesion. (Ref. 2)CD107a is principally expressed in epithelial cells and macrophages in a variety of organsin normal and Beige mutant mice. (Ref. 3)LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forminga barrier to lysosomal hydrolases. (Ref. 4)
UniProt P11438
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: < / = 1 µg/10e6 cells. (Ref.5)Immunohistochemistry on Frozen Sections. (Ref.5)Immunoaffinity Chromatography. (Ref.2)Western blot. (Ref.5)Immunoprecipitation. (Ref.1,3)Immunoelectron Microscopy. (Ref.6)Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 mM Borate Buffered Saline, pH 8.2.No preservatives or amine-containing buffer salts added.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Fukuda: "Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking." in: The Journal of biological chemistry, Vol. 266, Issue 32, pp. 21327-30, 1991 (PubMed).

Rohrer, Schweizer, Russell et al.: "The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane." in: The Journal of cell biology, Vol. 132, Issue 4, pp. 565-76, 1996 (PubMed).

Hosts (76), (63), (30), (1)
Reactivities (123), (70), (41), (8), (7), (5), (3), (2)
Applications (86), (81), (32), (28), (27), (26), (24), (22), (19), (10), (2), (1), (1)
Conjugates (19), (14), (13), (9), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (7), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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