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CD16 Molecule (CD16) antibody (PE)

Details for Product No. ABIN371545, Supplier: Log in to see
Antigen
  • Fcgr3
  • Fcgr3a
  • CD16
  • FCGR3
  • FCGR3@
  • CD16b
  • FCG3
  • FCR-10
  • FCRIII
  • FCRIIIb
  • FcRIII
  • Fc fragment of IgG, low affinity IIa, receptor
  • Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
  • Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
  • Fc receptor, IgG, low affinity III
  • Fc-gamma RIII
  • Fcgr2a
  • FCGR3A
  • FCGR3B
  • Fcgr3
  • FCGR3
Alternatives
anti-Human CD16 Molecule antibody for Flow Cytometry
Reactivity
Human
407
61
22
20
14
12
8
6
4
4
4
3
3
2
2
Host
Mouse
400
43
31
1
Clonality (Clone)
Monoclonal ()
Conjugate
PE
75
64
43
21
15
8
7
7
6
5
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
423
97
64
50
48
38
38
23
15
10
6
5
5
4
4
4
2
2
2
1
1
1
1
1
1
Options
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Clone GRM1
Isotype IgG2a
Specificity This antibody recognizes CD16/FcgammaRIII.
Characteristics Synonyms: CD16a, CD16b, FCG3, FCGR3, IGFR3, FCGR3B, Fc-gamma RIII, FcRIII, Low affinityimmunoglobulin gamma Fc region receptor III
Alternative Name CD16 (CD16 Antibody Abstract)
Background CD16 (FcgammaRIII) serves as a low affinity IgG receptor. Human CD16 is expressed in two forms CD16a and CD16b. CD16a is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. CD16b is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype. CD16 is involved in NK activation and signal transduction. (Ref.1-5)Synonyms: CD16A, FCG3, FCGR3, FCGR3A, Fc-gamma RIII, Fc-gamma RIII-alpha, Fc-gamma RIIIa, FcR-10, FcRIII, FcRIIIa, IGFR3, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A
Gene ID 2214
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Flow Cytometry: 10 μL/10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Takai, Li, Sylvestre, Clynes, Ravetch: "FcR gamma chain deletion results in pleiotrophic effector cell defects." in: Cell, Vol. 76, Issue 3, pp. 519-29, 1994 (PubMed).

Ravetch, Perussia: "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions." in: The Journal of experimental medicine, Vol. 170, Issue 2, pp. 481-97, 1989 (PubMed).